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There is limited clinical trial experience regarding human overdosage with Brexpiprazole (Rexulti).
Management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. Close medical supervision and monitoring should continue until the patient recovers.
Charcoal: Oral activated charcoal and sorbitol (50 g/240 mL), administered one hour after ingesting oral brexpiprazole, decreased brexpiprazole Cmax and area under the curve (AUC) by approximately 5% to 23% and 31% to 39% respectively; however, there is insufficient information available on the therapeutic potential of activated charcoal in treating an overdose with Brexpiprazole (Rexulti).
Hemodialysis: There is no information on the effect of hemodialysis in treating an overdose with Brexpiprazole (Rexulti); hemodialysis is unlikely to be useful because brexpiprazole is highly bound to plasma proteins.
