Seretide Dosage/Direction for Use

Salmeterol + Fluticasone propionate (Seretide) is for inhalation only.
Patients should be made aware that Salmeterol + Fluticasone propionate (Seretide) must be used regularly for optimum benefit, even when asymptomatic.
Patients should be regularly reassessed by a doctor, so that the strength of Salmeterol + Fluticasone propionate (Seretide) they are receiving remains optimal and is only changed on medical advice.
Asthma (Reversible Obstructive Airways Disease): The dose should be titrated to the lowest dose at which effective control of symptoms is maintained. Where the control of symptoms is maintained with twice daily Salmeterol + Fluticasone propionate (Seretide), titration to the lowest effective dose could include Salmeterol + Fluticasone propionate (Seretide) given once daily.
Patients should be given the strength of Salmeterol + Fluticasone propionate (Seretide) containing the appropriate fluticasone propionate dosage for the severity of their disease.
If a patient is inadequately controlled on inhaled corticosteroid therapy alone, substitution with Salmeterol + Fluticasone propionate (Seretide) at a therapeutically equivalent corticosteroid dose may result in an improvement in asthma control. For patients whose asthma control is acceptable on inhaled corticosteroid therapy alone, substitution with Salmeterol + Fluticasone propionate (Seretide) may permit a reduction in corticosteroid dose while maintaining asthma control.
Recommended Doses: There are no data available for use of Salmeterol + Fluticasone propionate (Seretide) in children aged under 4 years.
Diskus: Adults and adolescents 12 years and older: One inhalation (50 micrograms salmeterol and 100 micrograms fluticasone propionate) twice daily or One inhalation (50 micrograms salmeterol and 250 micrograms fluticasone propionate) twice daily or One inhalation (50 micrograms salmeterol and 500 micrograms fluticasone propionate) twice daily.
Children 4 years and older: One inhalation (50 micrograms salmeterol and 100 micrograms fluticasone propionate) twice daily.
MDI: Adults and adolescents 12 years and older: Two inhalations of 25 micrograms salmeterol and 50 micrograms fluticasone propionate twice daily or Two inhalations of 25 micrograms salmeterol and 125 micrograms fluticasone propionate twice daily or Two inhalations of 25 micrograms salmeterol and 250 micrograms fluticasone propionate twice daily.
Children 4 years and older: Two inhalations of 25 micrograms salmeterol and 50 micrograms fluticasone propionate twice daily.
Chronic Obstructive Pulmonary Disease (COPD): Diskus: For adult patients the recommended dose is one inhalation 50/250 micrograms to 50/500 micrograms salmeterol/fluticasone propionate twice daily.
MDI: For adult patients the recommended dose is two inhalations 25/125 micrograms to 25/250 micrograms salmeterol/fluticasone propionate twice daily.
Special patient groups: There is no need to adjust the dose in elderly patients or in those with renal or hepatic impairment.