Constipation is the most frequently reported adverse effect of sucralfate although diarrhea, nausea, vomiting, flatulence, or gastric discomfort may also occur. Other adverse effects include dry mouth, dizziness, drowsiness, headache, vertigo, back pain, and skin rashes. Hypersensitivity reactions such as pruritus, edema, urticaria, respiratory difficulty, rhinitis, laryngospasm, and facial swelling have been reported.