Sumatriptan and other serotonin (5-HT1) agonists (such as naratriptan, rizatriptan, zolmitriptan) should not be given with ergotamine or related compounds (including methysergide) since there is an increased risk of vasospastic reactions. In addition, a delay is advised before starting a serotonin (5-HT1) agonist in patients who have been receiving ergotamine or related compounds: sumatriptan should not be given until at least 24 hours after stopping the use of preparations containing ergotamine. Serotonin (5-HT1) agonists should not be given together. Sumatriptan should not be used with, and for 2 weeks after stopping, an MAOI. Use with the selective monoamine oxidase type B inhibitor selegiline is thought unlikely to provoke an interaction. St John's Wort (Hypericum perforatum). Taking herbal remedies that contain St. John's Wort together with Sutrip may make side effects more likely. Oral sumatriptan appeared to delay gastric emptying and might affect the absorption of other drugs, as judged by its delaying effect on paracetamol absorption in migraine patients.
Sign Out
