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Aminoglycosides: The mixing of Piperacillin and Tazobactam Sodium with an aminoglycosides in vitro can result in substantial inactivation of the aminoglycoside should be reconstituted and administered separately.
Probenecid: Probenecid administered concomitantly with Piperacillin and Tazobactam Sodium prolongs the half-life of piperacillin by 21% and that of tazobactam by 71%.
Vancomycin: No pharmacokinetic interactions have been noted between Piperacillin and Tazobactam Sodium and vancomycin.
Heparin: Coagulation parameters should be tested more frequently and monitored regularly during simultaneous administration of high doses of heparin, oral anticoagulants, or other drugs that may affect the blood coagulation system or the thrombocyte function.
Vecuronium: Piperacillin when used concomitantly with vecuronium has been implicated in the prolongation of the neuromuscular blockade of vecuronium.
