Tenofo-B Dosage/Direction for Use

Adults: The recommended dose for the treatment of HIV or for the treatment of chronic hepatitis B is 300 mg (one tablet) once daily taken orally with food.
Chronic hepatitis B: The optimal duration of treatment is unknown. Treatment discontinuation may be considered as follows: In HBeAg positive patients without cirrhosis, treatment should be administered for at least 6-12 months after HBe seroconversion (HBeAg loss and HBV DNA loss with antiHBe detection) is confirmed or until HBs seroconversion or there is loss of efficacy. Serum ALT and HBV DNA levels should be followed regularly after treatment discontinuation to detect any late virological relapse.
In HBeAg negative patients without cirrhosis, treatment should be administered at least until HBs seroconversion or there is evidence of loss of efficacy. With prolonged treatment for more than 2 years, regular reassessment is recommended to confirm that continuing the selected therapy remains appropriate for the patient.
Renal insufficiency: No dose adjustment is necessary for patients with mild renal impairment (creatinine clearance 50-80 mL/min). Routine monitoring of creatinine clearance and serum phosphorus should be performed in patients with mild renal impairment. Given as follows are the recommended dosing guidelines: See table.

Click on icon to see table/diagram/image

No dosing recommendation is available for patients with creatinine clearance <10 mL/min.