It should not be given to patient who are hypertensive to it or to other cephalosporin. About 10% of penicillin-sensitive patients may also be allergic to cephalosporins although the true incidence is uncertain; Great care should be taken if it is to be given to such patients. Care is also necessary in patients with a history of allergy. It should be given with caution to patients with renal impairment; a dosage of reduction may be necessary. Renal and haematological status should be monitored especially drug prolonged and high dose therapy.
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