Plasma-prolactin concentrations may be increased, which may lead to galactorrhea or gynecomastia, amenorrhea, breast tenderness, breast pain, irregular menstruation, and lactation disorder. There have been reports of reduced libido, and rashes and other allergic reactions. Domperidone does not readily cross the blood-brain barrier and the incidence of central effects such as extrapyramidal reactions or drowsiness
may be lower than with metoclopramide; however, there have been reports of dystonic reactions.
There have also been reports of depression, anxiety, headache, somnolence, akathisia, diarrhea, skin disorders like pruritus.