Torlos-50 Adverse Reactions

Side effects with Losartan have usually been mild and transient in nature and have not required discontinuation of therapy. The overall incidence of side effects reported with Losartan was comparable to placebo.
The following adverse events were reported at a rate of 1% or greater in patients treated with Losartan, but were as, or more frequent, in the placebo group: asthenia/fatigue, edema/swelling, abdominal pain, chest pain, nausea, headache, pharyngitis, diarrhea, dyspepsia, myalgia, Insomnia, cough, sinus disorder, muscle cramps, back and leg pain, dizziness, nasal congestion, upper respiratory infection and sinusitis.
In addition to the adverse events previously, potentially important events that occurred in <1% of patients In clinical studies are listed as follows. It cannot be determined whether these events were causally related to Losartan: Body as a Whole: facial edema, fever, orthostatic effects, syncope.
Cardiovascular: angina pectoris, second degree AV block, CVA, hypotension, myocardial infarction, arrhythmias including atrial fibrillation, palpitation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation.
Digestive: anorexia, constipation, dental pain, dry mouth, flatulence, gastritis, vomiting.
Hematologic: anemia.
Metabolic: gout.
Musculoskeletal: arm pain, hip pain, joint swelling, knee pain, musculoskeletal pain, shoulder pain, stiffness, arthralgia, arthritis, fibromyalgia, muscle weakness.
Nervous System/Psychiatric: anxiety, anxiety disorder, ataxia, confusion, depression, dream abnormality, hypesthesia, decreased libido, memory impairment, migraine, nervousness, paresthesia, peripheral neuropathy, panic disorder, sleep disorder, somnolence, tremor, vertigo.
Respiratory: dyspnea, bronchitis, pharyngeal discomfort, epistaxis, rhinitis, respiratory congestion.
Skin: alopecia, dermatitis, dry skin, ecchymosis, erythema, flushing, photosensitivity, pruritus, rash, sweating, urticaria.
Special Senses: blurred vision, burning/stinging in the eye, conjunctivitis, taste perversion, tinnitus, decrease in visual acuity.
Urogenital: impotence, nocturia, urinary frequency, urinary tract infection.
Persistent dry cough (with an incidence of a few percent) has been also associated with ACE-inhibitor use and in practice can be a cause of discontinuation of ACE-inhibitor therapy.