Not recommended for drug-induced extrapyramidal reactions. Patients w/ severe CV or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease, or history of PUD. Monitor cardiac function w/ particular care in patients w/ history of MI who have residual atrial nodal, or ventricular arrhythmias. Somnolence & episodes of sudden sleep onset. Monitor all patients for development of mental changes, depression w/ suicidal tendencies, & other serious antisocial behavior. Patients w/ current psychoses. Dyskinesias. May cause involuntary movements & mental disturbances. History of severe involuntary movements or psychotic episodes. Carefully observe any abrupt dosage reduction or w/drawal particularly in patients who are also receiving neuroleptics. Impulse control disorders. Carefully observe for loss of antiparkinsonian effect when concomitantly used w/ psycho-active drugs eg, phenothiazines or butyrophenones. History of convulsions. Periodic evaluation of hepatic, haematopoietic, CV & renal function during extended therapy. Chronic wide-angle glaucoma. Continue therapy for as long as patient is permitted to take fluids & medication if general anaesth is required. Monitor for melanomas on a regular basis. +ve Coombs test. May cause false +ve result when dipstick is used to test for urinary ketone. Use of glucose oxidase methods may give false -ve results for glycosuria. May affect ability to drive or operate machinery. Women of childbearing potential. Not recommended in childn <18 yr.
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