Pharmacology: Pharmacokinetics: Trimetazidine after oral administration, absorption of trimetazidine is rapid and the plasma peak is reached in less than 2 hours. After a single oral dose of 35 mg of trimetazidine, the peak plasma concentration is about 55 mg/mL. The apparent volume of distribution is 4.8 L/kg which suggests good tissue diffusion. Elimination of trimetazidine is principally urinary; mean half-life is 6 hours.
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