Silodosin is contraindicated in any of the following patient's conditions: Severe renal impairment (CrCl <30 mL/min).
Severe hepatic impairment (Child-Pugh score ≥10).
Concomitant administration with strong Cytochrome P450 3A4 (CYP3A4) inhibitors (e.g., ketoconazole, clarithromycin, itraconazole, ritonavir).
Patients with a history of hypersensitivity to Silodosin or any of the ingredients of Silodosin.