Sign Out
Cytotoxic Chemotherapy Drugs: No data are available on the safety of Febuxostat (Urica) during cytotoxic chemotherapy.
In-vivo Drug Interactions: No clinically significant interactions with Colchicine, Naproxen, Indomethacin, Hydrochlorothiazide, Warfarin or Desipramine were seen with Febuxostat (Urica). Dose adjustment is not needed.
Mercapturine, Azathioprine: Febuxostat (Urica) may cause increased plasma concentrations of those drugs resulting in toxicity.
Xanthine Oxidase (XO) Substrate Drugs: Febuxostat (Urica) was shown to alter metabolism of XO substrate drugs (eg. Theophylline). A 400-fold increase in the amount of 1-methylxanthin, a major metabolite of Theophylline, was excreted in urine. Use with caution when co-administering Febuxostat and Theophylline.
