Vaneular Indications/Uses

To treat deficiencies of vitamins B₁, B₂, B₆, B₁₂, and Nicotinic Acid manifested as: Muscle pain, loss of reflexes in the hands, knees, ankles, calves and feet and abnormal touch sensation such as burning and pricking.
As an adjunct in the management of conditions responsive to high dose vitamins B₁, B₂, B₆, B₁₂, and Nicotinic Acid which include the following: Neuralgia (nerve pain).
Neuritis (inflammation of the nerves).
Neuropathies (disturbances in the function of the brain or spinal cord that may affect the nerves and muscles of the body).
Inherited metabolic disorders such as: Leigh's necrotizing encephalopathy (a rare neurometabolic disorder characterized by degeneration or gradual loss of ability of the central nervous system, which includes the brain, spinal cord, and optic nerve, to function properly); Inherited vitamin B₆ dependency; Methylmalonic aciduria (the accumulation of methylmalonic acid in the body characterized by progressive encephalopathy (brain disease that gets worse), dehydration, developmental delays, constipation, seizures and vomiting).
Lactic acidosis (a disease caused by the build-up of lactic acid in the body characterized by deep and rapid breathing, vomiting, and abdominal pain).
Wernicke's encephalopathy (an alcohol-induced thiamine deficiency characterized by mental confusion, staggering, and constant rapid eye movements).
Beri-beri (thiamine deficiency manifested as muscle weakness, loss of appetite, nerve degeneration (inability of nerves to function properly).
Use of drugs such as isoniazid, cycloserine, penicillamine, hydralazine and levodopa which induces increased requirement for vitamin B₆.
Malabsorption syndromes.