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Hypersensitivity to the active substances or to any of the excipients listed in Description.
Use with potent P-gp and potent CYP inducers: Medicinal products that are potent P-glycoprotein (P-gp) or potent cytochrome P450 (CYP) inducers (rifampicin, rifabutin, St. John's wort [Hypericum perforatum], carbamazepine, phenobarbital and phenytoin). Co-administration will significantly decrease sofosbuvir or velpatasvir plasma concentrations and could result in loss of efficacy of Sofosbuvir and Velpatasvir tablets (see Interactions).
