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The recommended starting dose of Memantine Hydrochloride is 5 mg once daily. The recommended target dose is 20 mg/day. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice a day), 15 mg/day (5 mg and 10 mg as separate doses) and 20 mg/day (10 mg twice a day). The minimum recommended interval between dose increases is one week. Memantine Hydrochloride can be taken with or without food.
Doses in Special Populations: A target dose of 5 mg BID is recommended in patients with severe renal impairment or as directed by the physician.
