Patients w/ seizure disorder. Urinary elimination may be decreased resulting in increased plasma levels in conditions raising urine pH. Severe hepatic impairment. Not to be used during pregnancy & lactation.
Concomitant use w/ other NMDA antagonists eg, amantadine, ketamine & dextromethorphan. Co-administration of drugs using the same renal cationic system including hydrochlorothiazide, triamterene, metformin, cimetidine, ranitidine, quinidine & nicotine could potentially result in altered plasma levels of both agents. Reduced clearance w/ drugs that make urine alkaline.
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