Treatment & prevention of folate deficiency state. Women of childbearing potential & pregnant women to protect against neural tube defects in their offspring. Folate-deficient megaloblastic anaemia, chronic haemolytic states eg, thalassaemia major or sickle-cell anaemia.
Folate-deficient megaloblastic anaemia 5 mg daily for 4 mth. Up to 15 mg daily may be necessary in malabsorption states. Chronic haemolytic states eg, thalassaemia major or sickle-cell anaemia 5 mg every 1-7 days. Women of childbearing potential at high risk of having pregnancy affected by neural tube defect 4 or 5 mg daily starting before pregnancy & continued through the 1st trimester. Prophylaxis of folate deficiency in childn on dialysisChildn >12 yr 5-10 mg daily.
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