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Limited data are available with regard to overdose in humans. A single dose of 1200 mg and multiple doses of 900 mg (14 days) were studied in healthy volunteers and were well tolerated.
Hypotension is the most likely symptom of overdose due to the blood pressure lowering effects of sacubitril-valsartan (Vymada). Symptomatic treatment should be provided.
The medicinal product is unlikely to be removed by hemodialysis due to high protein binding.
