Reduced Xultophy requirement w/ anti-diabetics, MAOIs, β-blockers, ACE inhibitors, salicylates, anabolic steroids & sulfonamides. Increased Xultophy requirement w/ OCs, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormones & danazol. May mask symptoms of hypoglycemia w/ β-blockers. May either increase or decrease Xultophy requirement w/ octreotide/lanreotide. May intensify or reduce hypoglycemic effect w/ alcohol. Warfarin or other coumarin derivatives (may require more frequent INR monitoring).