Zefei Dosage/Direction for Use

Zefei is for IV use only.
Adults: Single-agent for Pancreatic Cancer: Administered by IV infusion at a dose of 1000 mg/m² over 30 min once weekly for up to 7 weeks (or until toxicity necessitates reducing or holding a dose), followed by a week of rest from treatment. Subsequent cycles should consist of infusions once weekly for 3 consecutive weeks out of every 4 weeks.
Combination Use for Non-Small Cell Lung Cancer: With the 4-week schedule, gemcitabine HCl should be administered IV at 1000 mg/m² over 30 min on days 1, 8 and 15 of each 28-day cycle. Cisplatin should be administered IV at 100 mg/m² on day 1 after the infusion of gemcitabine HCl. With the 3-week schedule, gemcitabine HCl should be administered IV at 1250 mg/m² over 30 min on days 1 and 8 of each 21-day cycle. Cisplatin at a dose of 100 mg/m² should be administered IV after the infusion of gemcitabine HCl on day 1.
Dosage Modification: Dosage adjustment for hematologic toxicity maybe required for gemcitabine HCl and cisplatin.
Reconstitution: To reconstitute, add 5 mL of 0.9% sodium chloride injection to the 200 mg vial or 25 mL of sodium chloride injection to the 1 g vial.
When prepared as directed, solutions are stable for 24 hrs at 25°C. Discard the unused portion.