Per 2 g/250 mg powd for inj Piperacillin Na 2 g, tazobactam Na 250 mg. Per 4 g/500 mg powd for inj Piperacillin Na 4 g, tazobactam Na 500 mg
Indications/Uses
For documented multidrug resistant gm -ve infections due to organisms proven or suspected to be susceptible to piperacillin-tazobactam except CNS infections; polymicrobial infections eg, mixed aerobic & anaerobic infections in which other agents have insufficient activity or are contraindicated due to toxic potential.
IV/IMAdultSerious complicated infections 200-300 mg/kg IV daily in divided doses. Usual dose: 3-4 g IV every 4-6 hr. Mild or uncomplicated infections 100-125 mg/kg daily. Usual dose: 2 g IV every 6-8 hr or 4 g IV every 12 hr, or 2 g IM every 8-12 hr. Uncomplicated gonorrhoea 2 g single dose IM. Prophylaxis infection during surgery 2 g pre-op.
Bleeding, clotting time, superinfections, organ system function assessment, fever & rash in cystic fibrosis patients, patients w/ syphilis, neutropenia & leucopenia may occur in prolonged use, possibility of hypokalemia, pregnancy & lactation.
J01CR05 - piperacillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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