Anapril has been demonstrated to be generally well-tolerated. For the most part, side effects have been mild and transient in nature and have not required discontinuation of therapy. Dizziness, Headache, Fatigue and Asthenia were reported. Other side effects occured in <2% of patients and included hypotension, orthostatic hypotension, syncope, nausea, diarrhea, muscle cramps, rash and cough.