Concomitant use of omeprazole & esomeprazole, fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, ciprofloxacin, cimetidine, carbamazepine, oxcarbazepine & chloramphenicol would reduce drug levels of active metabolite of clopidogrel & a reduction in clinical efficacy. Concomitant use of proton pump inhibitors should be avoided unless absolutely necessary. Concomitant administration of ASA co-administered w/ thrombolytic agents & heparin may lead to increased risk of bleeding. Concomitant administration of naproxen may increase occult GI blood loss.