Dapril has been found in controlled clinical trials to be generally well tolerated. For the most part, side effects were mild and transient in nature.
The most frequent clinical side effects of Dapril in controlled trials were: Dizziness (6.5%), headache (5.4%), diarrhoea (3.8%) and fatigue (2.9%).
Other side effects occurring less frequently, but in >1% of patients treated with Dapril, in controlled clinical trials were: Cough, nausea, rash, hypotension, orthostatic effects, palpitation, chest pain, asthenia.
Hypersensitivity/Angioneurotic Oedema: Angioneurotic oedema of the face, extremities, lips, tongue, glottis and/or larynx has been reported rarely (see Precautions).
Laboratory Test Findings: Clinically important changes in standard laboratory parameters were rarely associated with administration of Dapril. Increases in blood urea and serum creatinine, usually reversible upon discontinuation of Dapril have been seen.
Small decreases in haemoglobin and haematocrit, rarely of clinical importance unless another cause of anaemia coexisted, have occurred. Plasma potassium concentrations >5.7 mEq/L were reported in isolated instances in clinical trials, but were usually transient.