Cushing syndrome, GI ulcers, systemic fungal & herpes virus infections. Patients w/ TB, DM, osteoporosis, mental changes, cardiomyopathy, HTN, renal insufficiency should exercise caution. Avoid vaccination w/ small-pox. Prolonged treatment may produce the usual corticosteroid AR (eg, peptic ulcer, hypokalaemia, infections, CNS effects). Do not administer in pregnancy.