Discontinue at 1st appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity. Possible serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, & toxic epidermal necrolysis. Potentially fatal, upper GI complications (perforations, ulcers or bleedings) on patients most as risk (the elderly, those concomitantly using other NSAID or acetylsalicylic acid or w/ history of GI disease). Patients w/ significant risk factors for CV events (eg, HTN, hyperlipidaemia, DM, smoking). Not a substitute for acetylsalicylic acid for prophylaxis of CV thromboembolic diseases. Discontinue if condition of patients w/ history of cardiac failure, left ventricular dysfunction, or HTN & preexisting oedema deteriorates. Control HTN prior to treatment & monitor BP during treatment, w/in 2 wk after initiation of treatment & periodically thereafter. Dehydrated patients. May mask fever & other signs of inflammation. Concomitant use w/ warfarin or other oral anticoagulants. May affect ability to drive & use machines. Renal papillary necrosis & other renal injury in long-term administration. Monitor renal function in patients w/ preexisting significantly impaired renal function, uncompensated heart failure, or cirrhosis. Discontinue if signs of hepatic insufficiency occur or abnormal liver function tests (3 times the upper limit of normal) are persistently detected. Not recommended in women attempting to conceive. Elderly.