Forxiga Dosage/Direction for Use

Type 2 diabetes mellitus: The recommended dose of FORXIGA is 10 mg taken orally once daily at any time of the day regardless of meals.
Heart failure: The recommended dose of FORXIGA is 10 mg taken orally once daily at any time of the day regardless of meals.
Chronic kidney disease: The recommended dose of FORXIGA is 10 mg taken orally once daily at any time of the day regardless of meals.
Special populations: Patients with renal impairment: No dosage adjustment is required based on renal function.
Due to limited experience, it is not recommended to initiate treatment with FORXIGA in patients with GFR < 25 mL/min, however patients may continue 10 mg orally once daily to reduce the risk of eGFR decline, end-stage kidney disease and CV death.
The glucose lowering efficacy of FORXIGA is reduced in patients with eGFR <45 mL/min/1.73 m² (see Precautions and Pharmacology: Pharmacodynamics under Actions). Therefore, if eGFR falls below 45 mL/min/1.73 m², additional glucose lowering treatment should be considered in patients with diabetes mellitus.
Patients with hepatic impairment: No dosage adjustment for FORXIGA is necessary for patients with mild and moderate hepatic impairment. FORXIGA should not be used in patients with severe hepatic impairment (see Pharmacology: Pharmacokinetics under Actions).
Pediatric and adolescent patients: Safety and effectiveness of FORXIGA in pediatric and adolescent patients have not been established.
Geriatric patients: No dosage adjustment for FORXIGA is required based on age (see Pharmacology: Pharmacodynamics under Actions). Older patients are more likely to have impaired renal function. The renal function recommendations provided for all patients also apply to elderly patients (see Precautions).