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Cinacalcet occurs as a white to slightly yellowish white, crystalline powder. It is freely soluble in N,N-dimethylformamide, methanol, and ethanol (99.5), slightly soluble in water, and practically insoluble or insoluble in hexane. (See Table 1.)
Click on icon to see table/diagram/imageNonproprietary name: Cinacalcet hydrochloride.
Chemical Name: N-[(1R)-1-(Naphthalen-l-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine monohydrochloride.
Molecular formula: C22H22F3N•HCl.
Molecular weight: 393.87.
Melting point: Approximately 181°C.
Excipients/Inactive Ingredients: Partly pregelatinized starch, microcrystalline cellulose, povidone, crospovidone, light anhydrous silicic acid, talc, magnesium stearate, lactose hydrate, hypromellose, titanium oxide, triacetin, macrogol 400, yellow ferric oxide, blue No. 2 aluminium lake.
