May increase risk of AR eg, serotonin syndrome or attenuated effect of Remleas w/ MAOIs (eg, isocarboxazid, phenelzine, selegiline). Increased C
max & AUC w/ strong CYP3A4 (eg, itraconazole, ketoconazole, clarithromycin) & CYP2D6 (eg, paroxetine, fluoxetine, quinidine) inhibitors. Decreased exposure w/ strong CYP3A4 inducers (eg, rifampicin, carbamazepine, phenytoin, St. John's wort). Increased digoxin levels.