Hypersensitivity to the active substances or to any of the excipients.
Reactive airway disease including bronchial asthma, or a history of bronchial asthma, severe chronic obstructive pulmonary disease.
Sinus bradycardia, sick sinus syndrome, including sino-atrial block, second or third degree atrioventricular block not controlled with pace-maker.
Overt cardiac failure, cardiogenic shock.