Infections caused by tetracycline-sensitive organisms. Trachoma & inclusion conjunctivitis. Alternative drug for several infections when penicillin is contraindicated. Adjunctive therapy in amoebiasis & severe acne.
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals w/ a full glass of water in upright position. May be taken w/ meals to reduce GI discomfort.
Prolonged use may lead to overgrowth of nonsusceptible organisms including fungi. May depress plasma prothrombin activity. Not to be administered w/ penicillin, antacids. Monitor for dose-related BUN increase. Not recommended in lactation.
Impaired absorption by antacids. May require downward anticoagulant dosage adjustment on patients on anticoagulant therapy. May interfere w/ bactericidal action of penicillins. May render OCs less effective.
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