Adult Mild case of hyperthyroidism Initially 20 mg daily.
Inhibition of thyroid hormone production 25-40 mg daily.
Severe case of hyperthyroidism Initially 40 mg daily. Maintenance: Combination w/ levothyroxine: 5-20 mg daily; Monotherapy: 2.5 & 10 mg daily.
Long-term antithyroid therapy 2.5-10 mg/day.
Prophylactic treatment in patients w/ history of hyperthyroidism & autonomous adenomas in whom iodine exposure is indispensable 10-20 mg daily &/or perchlorate 1 g are administered for approx 10 days (eg, for renally excreted contrast media).
Childn Initially 0.3-0.5 mg/kg/day. After normalization of thyroid function, dose may be gradually reduced to 0.2-0.3 mg/kg/day.