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Overdosage of ceftazidime-avibactam is unlikely, although overdosing could potentially occur in patients with moderate to severe renal impairment, and in end stage renal disease including patients undergoing haemodialysis (see Precautions and Pharmacology: Pharmacokinetics under Actions). Overdosing with ceftazidime-avibactam can lead to neurological sequelae including encephalopathy, convulsions and coma, due to the ceftazidime component.
Treatment for overdose should follow local standard medical practice. Both ceftazidime and avibactam can be partially removed by haemodialysis.
