Myelofibrosis Differential Diagnosis

Acute myelofibrosis is a rare form of acute myeloid leukemia characterized by a non-palpable spleen with rapid onset of severe bone marrow fibrosis with fever and pancytopenia, teardrop-shaped red blood cells (RBCs), and leukoerythroblastic blood features.  

Other differentials include chronic myeloid leukemia, essential thrombocythemia, polycythemia vera, myelodysplastic syndrome, hairy cell leukemia, and multiple myeloma.