Administer as IV infusion over 30 min.
Adult Previously untreated HL In combination w/ AVD: 1.2 mg/kg as IV infusion over 30 min on days 1 & 15 of each 28-day cycle for 6 cycles.
HL at increased risk of relapse or progression 1.8 mg/kg as IV infusion over 30 min every 3 wk.
Patients following recovery from ASCT Receive treatment up to 16 cycles.
Relapsed or refractory HL & sALCL 1.8 mg/kg as IV infusion over 30 min every 3 wk.
Patients who have previously responded to treatment w/ Adcetris Retreatment: Initially 1.8 mg/kg as IV infusion over 30 min every 3 wk. Alternatively, start treatment at the last tolerated dose.
Patients who achieve stable disease or better Treat w/ min of 8 cycles & up to max of 16 cycles (approx 1 yr).
Previously untreated sALCL In combination w/ CHP: 1.8 mg/kg as IV infusion over 30 min every 3 wk for 6-8 cycles.
CTCL 1.8 mg/kg as IV infusion over 30 min every 3 wk up to 16 cycles.
Dose adjustments:
Patients who develop new or worsening peripheral sensory or motor neuropathy Grade 2: Monotherapy: Withhold dose until toxicity returns to ≤ Grade 1 or baseline, then restart at 1.2 mg/kg up to max of 120 mg every 3 wk. Combination therapy w/ AVD: Reduce dose to 0.9 mg/kg up to max of 90 mg every 2 wk; w/ CHP:
Motor neuropathy: Reduce dose to 1.2 mg/kg, up to max of 120 mg every 3 wk. Grade 3: Monotherapy: Withhold dose until toxicity returns to ≤ Grade 1 or baseline, then restart at 1.2 mg/kg up to max of 120 mg every 3 wk. Combination therapy w/ AVD: Withhold treatment until toxicity ≤Grade 2, then restart at 0.9 mg/kg up to max of 90 mg every 2 wk; w/ CHP:
Sensory neuropathy: Reduce dose to 1.2 mg/kg, up to max of 120 mg every 3 wk.
Patients w/ severe renal impairment (CrCl <30 mL/min) Monotherapy: 1.2 mg/kg up to a max of 120 mg every 3 wk,
mild (CrCl >50-80 mL/min) & moderate (CrCl 30-50 mL/min) renal impairment Monotherapy: 1.8 mg/kg up to max of 180 mg every 3 wk. Combination therapy w/ AVD: 1.2 mg/kg up to max of 120 mg every 2 wk.
Patients w/ severe (Child-Pugh C) or moderate (Child-Pugh B) hepatic impairment 1.2 mg/kg up to max of 120 mg every 3 wk,
mild (Child-Pugh A) hepatic impairment Monotherapy: 1.2 mg/kg up to max of 120 mg every 3 wk. Combination therapy w/ AVD: 0.9 mg/kg up to a max of 90 mg every 2 wk; w/ CHP: 1.2 mg/kg as IV infusion over 30 min every 3 wk.