Mild to moderate Alzheimer's disease, vascular dementia 5 or 10 mg once daily in the evening. Severe Alzheimer's disease 10 mg once daily in the evening.
May cause bradycardia &/or heart block w/ or w/o history of cardiac disease, syncopal episodes; dose-related diarrhea, nausea &/or vomiting; anorexia &/or wt loss. Sick sinus syndrome or other supraventricular cardiac conduction abnormalities, COPD, or asthma; history of seizure disorder; risk of ulcer disease (eg, previous history or NSAID use), or in patients w/ bladder outlet obstructions; dose-related diarrhea, nausea, &/or vomiting, anorexia &/or wt loss. Concomitant use w/ depolarizing neuromuscular blockers (eg, succinylcholine). May exaggerate succinyl-choline type muscle relaxation during anaesth. Closely monitor for symptoms of active or occult GI bleeding especially those w/ history of ulcer disease or receiving concurrent NSAIDs. Hepatic function impairment. Clastogenic effects. Pregnancy & lactation.
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