Amlopine Drug Interactions

Increased Effect/Toxicity: Amlodipine may increase the levels/effects of: amifostine, antihypertensives, CYP1A2 substrates, hypotensive agents, magnesium salts, neuromuscular-blocking agents (nondepolarizing), nitroprusside, phenytoin, rituximab, tacrolimus, tacrolimus systemic.
The levels/effects of amlodipine may be increased by: alpha1-blockers, antifungal agents (azole derivatives, systemic), calcium channel blockers (nondihydropyridine), cyclosporine, systemic, CYP3A4 inhibitors (moderate), CYP3A4 inhibitors (strong), dasatinib, diazoxide, fluconazole, grapefruit juice, herbs (hypotensive properties), macrolide antibiotics, magnesium salts, MAO inhibitors, pentoxifylline, phosphodiesterase-5 inhibitors, prostacyclin analogues, protease inhibitors, quinupristin.
Decreased Effect: Amlodipine may decrease the levels/effects of: clopidogrel, quinidine.
The levels/effects of amlodipine may be decreased by: barbiturates, calcium salts, carbamazepine, CYP3A4 inducers (strong), deferasirox, herbs (CYP3A4 inducers), herbs (hypertensive properties), methylphenidate, nafcillin, rifamycin derivatives, yohimbine.
Ethanol/Nutritional/Herb Interactions: Food: grapefruit juice may modestly increase amlodipine levels.
Herb/nutraceutical: St John's wort may decrease amlodipine levels. Avoid dong quai if using for hypertension (has estrogenic activity). Avoid ephedra, yohimbine, ginseng (may worsen hypertension). Avoid garlic (may have increased antihypertensive effects).