Amoksiklav

Co-amoxiclav (amoxicillin & clavulanic acid). Per 1 g Amoksiklav tab Amoxicillin 875 mg, clavulanic acid 125 mg

Infections of upper & lower resp tract, GUT, skin & soft tissue, bone & joint, dental. Cholecystitis. Mixed infections due to gm -ve & +ve microorganisms & anaerobes eg, chronic sinusitis & otitis, peritonsillar & mammary abscess, aspiration pneumonia, peritonitism cholangitis, post-op intra-abdominal complications, abdominal infections.

Tab Adult & childn >12 yr, weighing >40 kg Severe infections 1,000 mg tab bid.

May be taken with or without food: Best taken at the start of meals for better absorption & to reduce GI discomfort.

Hypersensitivity to penicillins or history of severe immediate hypersensitivity reactions eg, anaphylaxis to other β-lactam agents eg, cephalosporin, carbapenem or monobactam. History of jaundice or hepatic impairment.

Previous hypersensitivity reactions to penicillins, cephalosporins or other β-lactam agents; discontinue if occurs. Immediately discontinue if antibiotic-associated colitis occurs. Not to be used for penicillin-resistant S. pneumoniae. Acute generalised exanthemous pustulosis (AGEP). Atopic individuals. Switching from amoxicillin/clavulanic acid to amoxicillin. Avoid in suspected infectious mononucleosis. Overgrowth of non-susceptible organisms in prolonged use. Patients w/ serious underlying disease or taking concomitant medications known to have potential for hepatic effects. Antibiotic-associated colitis in patients w/ diarrhoea or subsequent to administration of any antibiotics. Periodically assess renal, hepatic & haematopoietic function during prolonged therapy. Appropriately monitor prothrombin time when using concomitantly w/ anticoagulants. Maintain adequate fluid intake & urinary output. Regularly check patency in patients w/ bladder catheters. Increased allergic reactions in concomitant use w/ allopurinol during treatment. False +ve results w/ non-enzymatic methods; Coombs' test. Convulsions may occur in patients w/ renal impairment or in those receiving high doses. May influence the ability to drive & use machines. Renal & hepatic impairment. Male patients. Pregnancy & lactation. Not recommended in childn <12 yr & weighing <40 kg. Elderly.

Diarrhoea. Mucocutaneous candidosis; nausea, vomiting.

Increased INR w/ acenocoumarol or warfarin. Reduced excretion of MTX. Decreased renal tubular secretion w/ probenecid. Concomitant use w/ mycophenolate mofetil. Amoxicillin: Increased & prolonged blood levels w/ probenecid.

Penicillins

J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.

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