CapPatient ≥17 yr w/ moderate to moderately severe chronic pain Not requiring rapid onset of analgesia: Dose titration: Initially 25 mg daily in the morning, increased by 25 mg increments every 3 days as separate doses up to 25 mg qid. Thereafter, increase dose by 50 mg every 3 days, up to 50 mg qid as tolerated. 50-100 mg every 4-6 hr as needed following titration. Requiring rapid onset of analgesia: 50-100 mg every 4-6 hr. Max: 400 mg daily. Renal impairment (CrCl <30 mL/min) 50-100 mg every 12 hr. Max: 200 mg daily. Hepatic cirrhosis 50 mg every 12 hr. AmpAdult & adolescent >14 yr 50-100 mg by slow IV, IM or SC. If required, may administer 50 mg 30 min to 1 hr after 1st dose. Max: 400 mg/day.
View Analab overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Known intolerance to other opioids. Acute intoxication w/ alcohol, hypnotics, narcotics, centrally acting analgesics, opioids or psychotropic drugs.
Serious & rarely fatal anaphylactoid reactions. Do not give in patients w/ history of anaphylactoid reactions to codeine & other opioids. Seizure following 1st episode; w/ naloxone administration. Patients at risk for resp depression; w/ increased ICP or head injury; w/ acute abdominal conditions. W/drawal symptoms may occur if discontinued abruptly. Advanced hepatic cirrhosis. Renal impairment. Not to be used in pregnant women prior to or during labor. Not recommended for obstet pre-op medication or post-delivery analgesia in nursing women. Childn <17 yr.
Sign Out
