Undiagnosed genital bleeding, known, past or suspected cancer of the breast, known or suspected estrogen-dependent malignant tumours (eg, endometrial cancer), untreated endometrial hyperplasia, previous idiopathic or current venous thromboembolism (deep venous thrombosis, pulmonary embolism), active or recent arterial thromboembolic disease (eg, angina, myocardial infarction), acute liver disease, or a history of liver disease as long as liver function tests have failed to return to normal, porphyria, severe renal insufficiency or acute renal failure, known hypersensitivity to the active substances or to any of the excipients of Angeliq.