Perform LFTs prior to the initiation of treatment & periodically thereafter; & in patients who develop liver injury. Monitor patients who develop increased transaminase levels until abnormalities resolved. Patients who consume substantial quantities of alcohol &/or have a history of liver disease; w/ prior hemorrhagic stroke or lacunar infarct. Patients w/ pre-disposing factors for rhabdomyolysis. Measure creatine kinase level before treatment in patients w/ renal impairment, hypothyroidism, personal or familial history of hereditary muscular disorders, previous history of muscular toxicity w/ a statin or fibrate, or of liver disease &/or where substantial quantities of alcohol are consumed, elderly >70 yr, situations where an increase in plasma levels may occur. Do not start if creatine kinase levels elevated to >5x ULN. Discontinue if clinically significant elevation of creatine kinase levels (>10x ULN) or rhabdomyolysis; ILD occurs. Concomitant use w/ potent CYP3A4 inhibitors or transport proteins [eg, ciclosporine, telithromycin, clarithromycin, delavirdine, stiripentol, ketoconazole, voriconazole, itraconazole, posaconazole & HIV PIs (eg, ritonavir, lopinavir, atazanavir, indinavir, darunavir, tipranavir/ritonavir)]; gemfibrozil & other fibric acid derivatives, antivirals for hepatitis C (boceprevir, telaprevir, elbasvir/grazoprevir), erythromycin, niacin or ezetimibe. Do not co-administer w/ systemic formulations of fusidic acid or w/in 7 days of stopping fusidic acid treatment. Monitor patients at risk of DM (fasting blood glucose 5.6-6.9 mmol/L, BMI >30 kg/m
2, raised triglycerides, HTN). Galactose intolerance, Lapp lactose deficiency or glucose-galactose malabsorption. Women of childbearing potential should use appropriate contraceptive measures during treatment.