Adult Colon, colorectal & breast cancer Monotherapy: Initially 1,250 mg/m
2 administered bid (morning & evening) for 2 wk followed by 1 wk rest period. Total daily dose: 2,500 mg/m
2.
Breast cancer In combination w/ docetaxel: Initially capecitabine 1,250 mg/m
2 bid for 2 wk followed by 1 wk rest period, combined w/ docetaxel 75 mg/m
2 as 1 hr IV infusion every 3 wk.
Colon, colorectal & oesophagogastric cancer Combination therapy: Initially capecitabine should be reduced to 800-1,000 mg/m
2 when administered bid for 2 wk followed by 1 wk rest period or 625 mg/m
2 bid when administered continuously. Duration for adjuvant treatment in stage III colon cancer: 6 mth.
Elderly ≥60 yr In combination w/ docetaxel: Initially dose reduction of capecitabine to 75% (950 mg/m
2 bid).
Moderate renal impairment Dose reduction to 75% for initial dose of 1,250 mg/m
2.