OA 200 mg as single dose; may be increased to 200 mg bid. RA 200 mg bid. Ankylosing spondylitis 200 mg as single dose up to total daily dose of 400 mg. Acute pain & primary dysmenorrhea Initially 400 mg followed by an additional 200 mg on the 1st day, if needed; subsequently 200 mg bid or 400 mg daily, as needed. Low back pain 200 mg or 400 mg daily as a single 200 mg dose or as 100 or 200 mg bid up to total daily dose of 400 mg throughout the course.
View Celebrex overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to celecoxib or sulfonamide. History of asthma, urticaria or allergic-type reaction after taking aspirin or NSAIDs. Treatment of peri-op pain in CABG surgery. Childn <18 yr.
Increased risk of serious CV thrombotic events, MI & stroke. May lead to the onset of new HTN or worsening of the preexisting HTN. Closely monitor BP during initiation & throughout the course of therapy in patients w/ HTN; preexisting CHF, edema, compromised cardiac function, or other conditions predisposing to or worsened by fluid retention including those taking diuretics or otherwise at risk of hypovolemia. Risk of developing GI complications in patients w/ CV disease, concomitant use w/ aspirin, glucocorticoids or other NSAIDs, alcohol; history of, or active GI disease eg, ulceration, GI bleeding or inflammatory conditions. Renal toxicity. Dehydrated patients; rehydrate patients prior to start of therapy. Closely monitor renal function in patients w/ advanced renal disease. Anaphylactoid reactions. Discontinue at 1st appearance of skin rash, mucosal lesions or any other signs of hypersensitivity. Moderate to severe hepatic impairment. Concomitant use w/ warfarin/coumarin-type & novel anticoagulants (eg, apixaban, dabigatran, rivaroxaban). Avoid concomitant use w/ non-aspirin NSAIDs. Pregnancy & lactation. Elderly <50 kg.
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