Cloril Adverse Reactions

Haematological: Granulocytopenia, agranulocytosis. Although generally reversible on withdrawal of the drug, agranulocytosis may be fatal. The majority of cases (approx. 85%) occur within the first 18 weeks of treatment. Immediate withdrawal of Clozapine is required if the patients develop agranulocytosis.
Leucocytosis and/or eosinophilia (especially in the initial weeks of treatment).
Thrombocytopenia.
Central nervous system: Fatigue, drowsiness and headache.
Confusion, restlessness, agitation, delirium.
EEG changes, seizure threshold decrement.
Extrapyramidal symptoms may occur. Rigidity, tremor and akathisia have been reported but acute dystonia is not an established side effect.
Cases of neuroleptic malignant syndrome (NMS) have been reported in patients receiving Clozapine either alone or in combination with lithium or other CNS-active agents.
Cardiovascular system: Tachycardia, postural hypotension with or without syncope, ECG changes.
Circulatory collapse, cardiac arrhythmias, pericarditis, myocarditis (with or without eosinophilia).
Autonomic nervous system: Dry mouth, blurred vision and disturbances in sweating and temperature regulation have been reported. Hypersalivation is a relatively common side effect.
Respiratory system: In isolated cases, without circulatory collapse, respiratory depression or arrest has occurred. Rarely, aspiration of ingested food may occur in patients presenting with dysphagia.
Gastro-intestinal system: Nausea, vomiting, constipation and, very rarely, ileus may occur.
Hepatitis and cholestatic jaundice may occur. If jaundice develops, Clozapine should be discontinued.
Clozapine treatment may be associated with dysphagia, a possible cause of aspiration.
There have also been reports of parotid gland enlargement.
Acute pancreatitis.
Genito-urinary system: Both urinary incontinence and urinary retention and, in a few cases, priapism have been reported.
Acute interstitial nephritis.
Miscellaneous: Skin reactions.
Benign hyperthermia may occur, especially in the initial weeks of treatment.
May be caused severe hyperglycemia.
Increases in CPK values have occurred.
With prolonged treatment considerable weight gain has been observed in some patients.