Adjunct to levodopa/benserazide or levodopa/carbidopa treatment in patients w/ Parkinson's disease & end-of-dose motor fluctuations, who cannot be stabilized on those combinations.
View Comtan overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Liver impairment. Pheochromocytoma. Concomitant use w/ nonselective MAO-A & MAO-B inhibitors. Concomitant use w/ a selective MAO-A plus a selective MAO-B inhibitor. History of NMS &/or non-traumatic rhabdomyolysis. Pregnancy & lactation.
Entacapone & Fe prep should be taken at least 2-3 hr apart. Dosage of levodopa & other antiparkinsonian drugs may need to be adjusted when entacapone treatment is initiated. Effects of medicinal products metabolized by catechol-O-methyl transferase may be potentiated.
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