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Pregnancy: There are no adequate and controlled studies to date using Celecoxib in pregnant women or during labor and delivery, the drug should be used during pregnancy only when the potential benefits justify the possible risk.
Celecoxib should not be used during the third trimester of pregnancy, since inhibitors of prostaglandin synthesis may have adverse effects on the fetal cardiovascular system (e.g. premature closure of the ductus arteriosus).
The use of a NSAID may be associated with an increased risk of miscarriage.
200 mg: NSAIDs exposure during the first trimester of pregnancy: Cardiovascular anomalies and cleft palate have been observed following NSAIDs exposure in some studies.
400 mg: If used during second or third trimester of pregnancy, NSAIDs may cause fetal renal dysfunction which may result in reduction of amniotic fluid volume or oligohydramnios in severe case. Such effects may occur shortly after treatment initiation and are usually reversible. Pregnant women on Celecoxib should be closely monitored for amniotic fluid volume.
Lactation: Small amounts of Celecoxib are found in breast milk. Because of the potential for adverse reactions in nursing infants from Celecoxib, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the expected benefit of the drug to the mother.
