Severe Alzheimer's dementia, other types of dementia or other types of memory impairment (eg, age-related cognitive decline). Concomitant use w/ anesth. May have vagotonic effects on heart rate (eg, bradycardia); bladder outflow obstruction. Monitor symptoms in patients who are at risk for developing ulcers eg, history of ulcer disease or receiving NSAIDs. Potential to exacerbate or induce extrapyramidal symptoms. Discontinue treatment if NMS occurs. History of asthma or obstructive pulmonary disease. Avoid concomitant use w/ other acetylcholinesterase inhibitors, cholinergic system agonists or antagonists. Severe hepatic impairment. May impair ability to drive or use machines. Pregnancy & lactation. Childn, adolescents & <18 yr.