Dymista Description

One actuation (0.14 g) delivers azelastine hydrochloride 137 micrograms and fluticasone propionate 50 micrograms.
Azelastine hydrochloride is a white, odorless, crystalline powder with a bitter taste. It has a molecular weight of 418.37. It is sparingly soluble in water, methanol, and propylene glycol and slightly soluble in ethanol, octanol, and glycerin. It has a melting point of 225°C and the pH of 5.2. Its chemical name is (±)-1-(2H)-phthalazinone,4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-,monohydrochloride.
Its molecular formula = C₂₂H₂₄ClN₃O·HCl.
Fluticasone propionate is a synthetic corticosteroid, a white powder with a melting point of 273°C, a molecular weight of 500.6. It is practically insoluble in water, freely soluble in dimethyl sulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol. Fluticasone propionate having the chemical name S-(fluoromethyl)-6alpha,9-difluoro-11 Beta,-17-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17 Beta-carbothioate, 17-propionate, the molecular formula = C₂₅H₃₁F₃O₅S.
Excipients/Inactive ingredients: Disodium edetate, glycerol, microcrystalline cellulose, carmellose sodium, polysorbate 80, benzalkonium chloride, phenylethyl alcohol and purified water.