Dynastat Caution For Usage

Special Precautions for Disposal and Other Handling: Parecoxib sodium for injection is a preservative-free lyophilized powder. Parecoxib sodium should be reconstituted with 1 mL (20 mg vial) or 2 mL (40 mg vial) Sodium Chloride Injection (0.9%).
Alternatively, parecoxib sodium may be reconstituted with bacteriostatic 0.9% Sodium Chloride Injection, 5% Dextrose Injection or 5% Dextrose and 0.45% Sodium Chloride Injection.
Use of Lactated Ringer's Injection, or 5% Dextrose in Lactated Ringer's Injection, are not recommended for reconstitution as they will cause the drug to precipitate from solution. Use of Water for Injection is not recommended for reconstitution of parecoxib sodium, as the resulting solution is not isotonic.
Do not refrigerate or freeze the reconstituted product.
Incompatibilities: Following reconstitution with an acceptable diluent, parecoxib sodium may be injected into an IV line delivering 0.9% Sodium Chloride Injection, 5% Dextrose Injection, Lactated Ringer's Injection, or 5% Dextrose and 0.45% Sodium Chloride Injection.
Injection into a line delivering 5% Dextrose in Lactated Ringer's, or other IV fluid not listed here, is not recommended, as this may cause precipitation from solution.
Parecoxib sodium should not be admixed for injection with any other drug.
Do not inject parecoxib into an IV line delivering any other drug. The IV line must be adequately flushed prior to, and after parecoxib injection with a solution of known compatibility (see Special Precautions for Disposal and Other Handling in the previous text).